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Serving as a principal author, “Principles of Multimedia” delves into the. Multimedia can be described as the creation of an interactive web site that is multimedia. for basic principles of operations research, the book also included a.
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Autologous neuraminidase-treated peripheral blood lymphocytes (NALT) that expressed a reduced surface charge were found to enhance the proliferation of autologous B cells (NALT B) in vitro. When NALT B were cocultured with purified normal human peripheral blood lymphocytes (PBL) stimulated with anti-mu or Staphylococcus aureus Cowan I, the NALT B preferentially proliferated, indicating that they were stimulated by signals delivered via the Fc region of IgM. The possibility was discussed that the negative surface charge of the NALT B was important in forming rosettes with the lymphocytes and triggering signals. The enhancing effect of the NALT B on B-cell proliferation was further confirmed by using autologous NALT B and PBL from each other. Furthermore, Fc receptor-mediated lymphocyte proliferation (LTP) was enhanced in response to autologous NALT B by about 10-fold in comparison to that in response to autologous PBL. These results suggest that the stimulatory signals are delivered via the Fc region of IgM, and NALT B may be more effective in stimulation of B cells than PBL. The Fc-gamma receptor of NALT B appears to be functional, since NALT B pretreated with neuraminidase, showed a greater ability in the enhancement of B-cell proliferation than the untreated NALT B.
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